000			02881nam a22001937a 4500
003			KE-MeUCS
005			20221102123556.0
008			221102b xxu||||| |||| 00| 0 eng d
020			_a
040			_cKE-MeUCS _dKE-MeUCS
050			_aRA644.M8 2022
100			_aMurungi, Jane Nkirote
245			_aA deterministic analysis of the effectiveness of non-clinical approaches in the control of transmission of schistosomiasis case study of Mwea irrigation scheme Kenya / _cJane Nkirote Murungi
250			_a
260			_aMeru: _bMeru University of Science and technology, _c2022.
300			_axi,94 p.
520			_aSchistosomiasis commonly known as bilharzia is regarded by WHO as a neglected tropical disease. It affects the intestines and the urinary system preferentially, but can harm other systems in the body. The disease is a health concern among majority of the population in Mwea irrigation scheme in Kenya and indeed, other tropical countries. In this study, a deterministic analysis of the effectiveness of non-clinical approaches in reducing the transmission of bilharzia in the region is carried out. A SIRS based mathematical model that incorporates media campaigns as a control strategy of reducing transmission of the disease is formulated. The model considers behavior patterns of hosts as the main process of transmission of the disease. The dynamics of these processes is expressed in terms of ordinary differential equations deduced from the flow chart which are solved numerically. The reproduction number Ro and equilibrium points both DFE and EE are obtained. The stabilities of these equilibrium points are analyzed in reference to the reproduction number (Ro). Secondary data from Mwea by Okonjo et al., 2017 and Ngigi et al., 2019 were used in the developed SIR based mathematical model and in the prediction of the dynamics estimated in the model for a period of five years. Numerical simulation was carried out for a period of five years and results represented graphically. The results of the simulation show that the infected decreases from 75108 to about 35000 and the susceptible from 325142 to about 50000 respectively in a period of five years. From the analysis, the disease free equilibrium (DFE) point is asymptotically stable when Ro<1. Sensitivity analysis of various parameters was carried out using partial differentiation and their results tabulated. The results show that the sensitivity index of most parameters are negative, therefore they are inversely proportional to Ro which will reduce schistosomiasis infection. The results revealed that incorporation of media campaigns as a control strategy significantly reduces transmission of the disease. The results will be useful to MOH to enhance media campaigns to prevent spread of schistosomiasis in Mwea irrigation scheme and other endemic areas.
942			_2lcc _cPER _tIN
999			_c88257 _d88256